Direct the Muscle Biology Laboratory
Coordinate the Exercise Science (M.S.) and Kinesiology (Ph.D.) graduate programs
Teach in exercise science curriculum at the bachelor’s, masters’, and doctoral levels
Direct and serve on masters’ thesis and doctoral dissertation committees
Serve on departmental, college, and university committees
Serve as faculty advisor to the GSU Triathlon Club

My research goals are to elucidate the molecular and cellular causes of strength loss and recovery associated with skeletal muscle injury and disease.  The primary type of muscle injury we study muscle is caused by exercise and/or muscle disease. Functional deficits arising from muscle injury and/or disease can result in significant impairment in motor performance, whether on the athletic field or in the work place.  Using embryonic stem cell technology, my collaborator at Baylor College of Medicine has created mouse models of the human muscle diseases Malignant Hyperthermia and Central Core Disease.  These muscle diseases are thought to stem from genetic mutations involving the intracellular ryanodine receptor protein complex.  The ryanodine protein interacts with several other proteins (e.g., FKBP12) to regulate intracellular calcium release and muscle force production. Our research studies seek to understand how these mutations affect skeletal muscle intrinsic function, disease pathology, susceptibility to fatigue and injury, and recovery from exercise-induced injury.  The Muscle Biology Laboratory in the Department of Kinesiology and Health is equipped to study these questions using physiological, histological, biochemical, and molecular biological techniques.

Recent Publications

Journal Articles:
Corona, B, C. Rouviere, S.L. Hamilton, and C.P. Ingalls. Eccentric Contractions Do Not Induce Rhabdomyolysis in Malignant Hyperthermia Susceptible Mice (Submitted to J. Appl. Physiol.)

Corona, B, C. Rouviere, S.L. Hamilton, and C.P. Ingalls. FKBP12 deficiency reduces strength deficits after eccentric contraction-induced injury. J. Appl. Physiol. (In press)

Green, M.S., B.T. Corona, J.A. Doyle, and C.P. Ingalls. A carbohydrate-protein drink does not enhance recovery from exercise-induced muscle injury. International Journal of Sport Nutrition & Exercise Metabolism. 18: 1-18, 2008.

Hubal, M.J., C.P. Ingalls, M.R. Allen, J.C. Wenke, H.A. Hogan, and S.A. Bloomfield. Effects of eccentric exercise training on cortical bone and muscle strength in estrogen-deficient mouse.  J. Appl. Physiol.. 98: 1674-1681, 2005.

Tang, W., C.P. Ingalls, W.J. Durham, J. Snider, M.B. Reid, G. Wu, M.M. Matzuk, and S.L. Hamilton.  Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency. FASEB J. 18:1597-9, 2004.

Ingalls, C.P., J.C. Wenke, T. Nofal, and R.B. Armstrong.  Adaptation to lengthening contraction-induced injury in mouse muscle.  Journal of Applied Physiology. 97: 1067-1076, 2004.

Ingalls, C.P., G.L. Warren, J. Zhang, S.L. Hamilton, and R.B. Armstrong.  Dihydropyridine and ryanodine receptor binding after eccentric contractions in mouse skeletal muscle.  J. Appl. Physiol. 96: 1619-1625, 2004.

Ingalls, C.P.  Nature vs. nurture: can exercise really alter fiber type composition in human skeletal muscle. J. Appl. Physiol. 97: 1591-1592, 2004.

Contact information:

Telephone: (404) 413-8377
E-mail: cingalls@gsu.edu

Mailing address:

Dept. of Kinesiology and Health
Georgia State University
P.O.Box 3975
Atlanta, GA. 30302-3975